Toleransen for høye doser kan avta raskt dersom gentleman slutter med opioider eller har en pause i bruk. I slike tilfeller er man spesielt utsatt for overdoser dersom person inntar samme dose som tidligere.Helle omtaler de to klassiske former: Infiltrationsanalgesi og ledningsanalgesi, hvoraf infiltrationsanalgesien er den klart nemmeste at gå t

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